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Benazir Khurshid PhD thesis

Organic/inorganic interface in biominerals: unveiling the complex structure of two calcitic biomineral models, the red coral Corallium rubrum and the fan mussel Pinna nobilis

Funding: ANR MOBi

Started in october 2019

Supervisor: Frédéric Marin ; cosupervisor: Jonathan Perrin (Synchrotron SOLEIL)

 

Abstract

Biominerals are organo-minerals structures produced by living systems. Since the Cambrian, they contribute to the adaptation of living organisms to different environments by fulfilling a variety of functions that go along with adapted morphologies. One of the aims of biomineralization is to understand how organisms “sculpt” these complex morphologies at nano and molecular scales: we know that occluded organic matrix proteins influence the lattice parameters of biominerals and that many of them strongly interact with the mineral phase in in vitro assays, but their exact roles are still to be known. The aim of the PhD of Benazir Khurshid is to understand the complex relationships between the organic and mineral phases. To this end, this work explores two calcitic models, the red coral Corallium rubrum and the prismatic shell layer of the Mediterranean fan mussel Pinna nobilis. Both models are analyzed by combining the physical techniques of Synchrotron SOLEIL and the biochemical approaches developed at Biogeosciences Dijon.

 

Keywords

biomineralization, calcite, Pinna nobilis, Corallium rubrum, AFM, proteomics, skeletal matrix

extrait:
lien_externe:
titre:
Interfaces organo-minéraux dans les biominéraux
date_de_debut_these:
octobre 2019
nom:
Khurshid
date_de_debut_these_numerique:
201910
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kc_raw_content:

Organic/inorganic interface in biominerals: unveiling the complex structure of two calcitic biomineral models, the red coral Corallium rubrum and the fan mussel Pinna nobilis

Funding: ANR MOBi

Started in october 2019

Supervisor: Frédéric Marin ; cosupervisor: Jonathan Perrin (Synchrotron SOLEIL)

 

Abstract

Biominerals are organo-minerals structures produced by living systems. Since the Cambrian, they contribute to the adaptation of living organisms to different environments by fulfilling a variety of functions that go along with adapted morphologies. One of the aims of biomineralization is to understand how organisms "sculpt" these complex morphologies at nano and molecular scales: we know that occluded organic matrix proteins influence the lattice parameters of biominerals and that many of them strongly interact with the mineral phase in in vitro assays, but their exact roles are still to be known. The aim of the PhD of Benazir Khurshid is to understand the complex relationships between the organic and mineral phases. To this end, this work explores two calcitic models, the red coral Corallium rubrum and the prismatic shell layer of the Mediterranean fan mussel Pinna nobilis. Both models are analyzed by combining the physical techniques of Synchrotron SOLEIL and the biochemical approaches developed at Biogeosciences Dijon.

 

Keywords

biomineralization, calcite, Pinna nobilis, Corallium rubrum, AFM, proteomics, skeletal matrix

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