Development and evolution of the craniofacial complex in rodents

Started in October 2018

Funding: doctoral grant

Supervisor: Sophie Montuire ; co-supervisor: Nicolas Navarro

Defense the 9 november 2022

Abstract

The skull is, architecturally and functionally, a strongly integrated and complex structure. At the same time and somehow paradoxically, this unit is highly evolvable and presents a high diversity of shapes. Epigenetic interactions in response to mechanical stimulations will compensate and coordinate the growth of the different organs constituting the head, in order to acquire and/or to maintain certain functions. These interactions will allow the normal development by controlling the bone remodeling. In spite of its central role, the importance of these interactions in the expression of differences between species and at a large time‐scale in the dynamics of clades remains poorly understood. The project of the PhD thesis aims I) at studying the onset of the craniofacial disparity in rodents during development, and II) at estimating the importance of the epigenetic processes during this postnatal growth.

Jury

Irina Ruf, Senckenberg Museum (Germany), reviewer
Marcelo Sanchez-Villagra, Zurich University (Switzerland), reviewer
Allowen Evinu, Montpellier University, examiner
Vincent Debat, MNHN, examiner
Emmanuel Fara, Bourgogne Franche-Comté University, examiner
Sophie Montuire, EPHE, supervisor
Nicolas Navarro, EPHE, cosupervisor

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Development and evolution of the craniofacial complex in rodents

Started in October 2018

Funding: doctoral grant

Supervisor: Sophie Montuire ; co-supervisor: Nicolas Navarro

Defense the 9 november 2022

 

Abstract

The skull is, architecturally and functionally, a strongly integrated and complex structure. At the same time and somehow paradoxically, this unit is highly evolvable and presents a high diversity of shapes. Epigenetic interactions in response to mechanical stimulations will compensate and coordinate the growth of the different organs constituting the head, in order to acquire and/or to maintain certain functions. These interactions will allow the normal development by controlling the bone remodeling. In spite of its central role, the importance of these interactions in the expression of differences between species and at a large time‐scale in the dynamics of clades remains poorly understood. The project of the PhD thesis aims I) at studying the onset of the craniofacial disparity in rodents during development, and II) at estimating the importance of the epigenetic processes during this postnatal growth.

 

Jury

Irina Ruf, Senckenberg Museum (Germany), reviewer
Marcelo Sanchez-Villagra, Zurich University (Switzerland), reviewer
Allowen Evinu, Montpellier University, examiner
Vincent Debat, MNHN, examiner
Emmanuel Fara, Bourgogne Franche-Comté University, examiner
Sophie Montuire, EPHE, supervisor
Nicolas Navarro, EPHE, cosupervisor